Metabolic action of metformin
I Szymczak-Pajor, S Wenclewska, A Śliwińska - Pharmaceuticals, 2022 - mdpi.com
Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism,
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …
Multifaceted mechanisms of action of metformin which have been unraveled one after another in the long history
H Kaneto, T Kimura, A Obata, M Shimoda… - International Journal of …, 2021 - mdpi.com
While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review
article, we focus on metformin which is an insulin sensitizer and is often used as a first …
article, we focus on metformin which is an insulin sensitizer and is often used as a first …
Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study
Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022 - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
Molecular action of metformin in hepatocytes: an updated insight
A Sliwinska, J Drzewoski - Current diabetes reviews, 2015 - ingentaconnect.com
Although, metformin is a drug of the first choice in the treatment of type 2 diabetes mellitus,
its molecular action is not fully determined. It is widely accepted that the antihyperglycemic …
its molecular action is not fully determined. It is widely accepted that the antihyperglycemic …
Metformin and metabolic diseases: a focus on hepatic aspects
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of
type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses …
type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses …
Metformin and systemic metabolism
L He - Trends in Pharmacological Sciences, 2020 - cell.com
Metformin can improve patients' hyperglycemia through significant suppression of hepatic
glucose production. However, up to 300 times higher concentrations of metformin …
glucose production. However, up to 300 times higher concentrations of metformin …
[PDF][PDF] Metformin and its gastrointestinal problems: A review
M Fatima, S Sadeeqa, SUR Nazir - Biomed Res, 2018 - academia.edu
Metformin is a biguanide class of drugs and has been recommended as first-line therapy for
type 2 diabetes. It has a good safety profile, efficacy, comparatively reduced cost, and …
type 2 diabetes. It has a good safety profile, efficacy, comparatively reduced cost, and …
Integrated or independent actions of metformin in target tissues underlying its current use and new possible applications in the endocrine and metabolic disorder area
G Tulipano - International journal of molecular sciences, 2021 - mdpi.com
Metformin is considered the first-choice drug for type 2 diabetes treatment. Actually,
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …
[HTML][HTML] Current understanding of metformin effect on the control of hyperglycemia in diabetes
Metformin is a first line oral anti-diabetic agent that has been used clinically to treat patients
with type 2 diabetes for over 60 years. Due to its efficacy in therapy and affordable price …
with type 2 diabetes for over 60 years. Due to its efficacy in therapy and affordable price …
A reappraisal on metformin
T Adak, A Samadi, AZ Ünal, S Sabuncuoğlu - Regulatory Toxicology and …, 2018 - Elsevier
This review investigates the different biological effect of Metformin (MET) in different
conditions. MET is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus …
conditions. MET is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus …