Hepatitis B virus (HBV) is tightly controlled by a number of noncytotoxic mechanisms. This
control occurs within the host hepatocyte at different steps of the HBV replication cycle. HBV …

Hepatitis B virus (HBV) infects humans and certain nonhuman primates. Viral clearance and
acute disease are associated with a strong, polyclonal, multispecific cytotoxic T lymphocyte …

Hepatitis B virus (HBV) is a major human pathogen lacking a reliable curative therapy.
Current therapeutics target the viral reverse transcriptase/DNA polymerase to inhibit viral …

Hepatitis B virus (HBV) replicates by the reverse transcription of the 3.5-kb viral pregenomic
RNA. Therefore, the regulation of the transcription of the pregenomic RNA is a critical step in …

The precise modulation of hepatitis B virus (HBV) gene expression is essential for
replication of the virus. HBV sequences are transcribed under the control of the …

The hepatitis B virus has a compact genome, yet codes for at least seven primary translation
products. Not surprisingly, the cis-acting elements that regulate gene expression overlap …

Abstract Hepatitis B virus (HBV) DNA contains consensus elements for transactivating
proteins whose binding activity in other systems is regulated by inflammatory cytokines …

Hepadnaviruses multiply their DNA genome by reverse transcription of an RNA
intermediate, termed pregenomic RNA. Therefore, hepadnaviral transcription has a dual …

Hepatitis B virus (HBV) infection, either acute or chronic, has been one of the leading health
problems in the world. To understand the HBV life cycle and disease process, we set out to …

The core promoter of hepatitis B virus shows hepatocyte specificity, which is largely
dependent on an upstream regulatory sequence that overlaps with viral enhancer II …