mRNA stability is a major determinant of inflammatory gene expression. Rapid degradation
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …

The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …

AU-rich elements (ARE) present in the 3′ untranslated regions of many cytokines and
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …

Transient expression of some proto-oncogenes, cytokines, and transcription factors occurs
as a cellular response to growth factors, 12-O-tetradecanoylphorbol-13-acetate, antigen …

The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at
which the mRNA decays. Because decay rates affect the expression of specific genes, they …

Many studies have highlighted the importance of the tight regulation of mRNA stability in the
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …

Control of mRNA turnover is an integral component of regulated gene expression. Individual
mRNAs display a wide range of stabilities, which in many cases have been linked to discrete …

Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in
humans and it has also been implicated in tumorigenesis. However, the underlying …

Regulation of gene expression is essential for the homeostasis of an organism, playing a
pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple …

Transcriptional control mechanisms chart the course of the inflammatory response by
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …