Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets
R Winzen, BK Thakur, O Dittrich-Breiholz… - … and cellular biology, 2007 - Taylor & Francis
mRNA stability is a major determinant of inflammatory gene expression. Rapid degradation
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …
Post-transcriptional control of cytokine production
P Anderson - Nature immunology, 2008 - nature.com
The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase
XF Ming, G Stoecklin, M Lu, R Looser… - Molecular and cellular …, 2001 - Taylor & Francis
AU-rich elements (ARE) present in the 3′ untranslated regions of many cytokines and
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …
An A+U-Rich Element RNA-Binding Factor Regulates c-myc mRNA Stability In Vitro
G Brewer - Molecular and cellular biology, 1991 - Taylor & Francis
Transient expression of some proto-oncogenes, cytokines, and transcription factors occurs
as a cellular response to growth factors, 12-O-tetradecanoylphorbol-13-acetate, antigen …
as a cellular response to growth factors, 12-O-tetradecanoylphorbol-13-acetate, antigen …
The cap-to-tail guide to mRNA turnover
CJ Wilusz, M Wormington, SW Peltz - Nature reviews Molecular cell …, 2001 - nature.com
The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at
which the mRNA decays. Because decay rates affect the expression of specific genes, they …
which the mRNA decays. Because decay rates affect the expression of specific genes, they …
[HTML][HTML] The emerging role of RNA modifications in the regulation of mRNA stability
SH Boo, YK Kim - Experimental & molecular medicine, 2020 - nature.com
Many studies have highlighted the importance of the tight regulation of mRNA stability in the
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
The search for trans-acting factors controlling messenger RNA decay
GM Wilson, G Brewer - Progress in nucleic acid research and molecular …, 1998 - Elsevier
Control of mRNA turnover is an integral component of regulated gene expression. Individual
mRNAs display a wide range of stabilities, which in many cases have been linked to discrete …
mRNAs display a wide range of stabilities, which in many cases have been linked to discrete …
Linc-RoR promotes c-Myc expression through hnRNP I and AUF1
Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in
humans and it has also been implicated in tumorigenesis. However, the underlying …
humans and it has also been implicated in tumorigenesis. However, the underlying …
MRNA stability and the control of gene expression: implications for human disease
EM Hollams, KM Giles, AM Thomson… - Neurochemical …, 2002 - Springer
Regulation of gene expression is essential for the homeostasis of an organism, playing a
pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple …
pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple …
Post-transcriptional regulons coordinate the initiation and resolution of inflammation
P Anderson - Nature Reviews Immunology, 2010 - nature.com
Transcriptional control mechanisms chart the course of the inflammatory response by
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …
synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these …