Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-
mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre …

Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …

In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation
via calcium-dependent mRNA stabilization. We performed a mutational analysis of the 8 …

Regulation of the cytoplasmic stability of mRNAs has recetly been identified as a major
control mechanism which governs mRNA levels in a variety of eukaryotic systems. In this …

Posttranscriptional control of mRNA regulates various biological processes, including
inflammatory and immune responses. RNA-binding proteins (RBPs) bind cis-regulatory …

Transcription and RNA decay are key determinants of gene expression; these processes are
typically considered as the uncoupled beginning and end of the messenger RNA (mRNA) …

When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

Background Microarray technology has become highly valuable for identifying complex
global changes in gene expression patterns. The effective correlation of observed changes …

The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in
dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated …

During the last decade evidence has accumulated that modulation of mRNA stability plays a
central role in cellular homeostasis, including cell differentiation, proliferation and adaptation …