Cryptococcus neoformans is the causative agent of cryptococcal meningoencephalitis.
There is accumulating evidence that C. neoformans is a facultative intracellular pathogen …

Cryptococcus species are encapsulated fungi found in the environment that predominantly
cause disease in immunocompromised hosts after inhalation into the lungs. Even with …

The fungal pathogen Cryptococcus neoformans is killed by the bacterium Staphylococcus
aureus, and the killing is inhibited by soluble capsular polysaccharides. To investigate the …

Increasing resistance to frontline antifungals is a growing threat to global health. In the face
of high rates of relapse for patients with cryptococcal meningitis and frequent drug …

Cryptococcus neoformans capsule structure modifications after prolonged in vitro growth or
in vivo passaging have been reported previously. However, nothing is known about the …

Iron overload is known to exacerbate many infectious diseases, and conversely, iron
withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for …

The antiphagocytic polysaccharide capsule of the human fungal pathogen Cryptococcus
neoformans is a major virulence attribute. However, previous studies of the pleiotropic …

Cryptococcus spp. cause fungal meningitis, a life-threatening infection that occurs
predominately in immunocompromised individuals. In order for Cryptococcus neoformans to …

Background. Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality
globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor fungal …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. C. neoformans
resides within mature phagolysosomes where it often evades killing and replicates. C …