Tumor angiogenesis plays a central role in the development and metastasis of
hepatocellular carcinoma. Cancer cells secrete angiogenic factors to recruit vascular …

Hepatocellular carcinoma (HCC) progression is closely related to pathological fibrosis,
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …

Background: Liver cancer with portal vein tumor thrombus (PVTT) indicates a serious
prognosis. The molecular mechanism of PVTT formation is not totally clarified, the invasion …

Background It is well documented that cancer cells secrete angiogenic factors to recruit and
sustain tumor vascular networks. However, little is known about the effects of endothelial …

Objective To explore the effect of two dominating signaling pathways, VEGF/KDR and
angiopoietins/Tie2, on the formation of new blood vessel in hepatocellular carcinoma (HCC) …

Blood vessel remodeling is crucial in tumor growth. Growth factors released by tumor cells
and endothelium-extracellular matrix interactions are highlighted in tumor angiogenesis …

Despite progress in diagnosis and treatment of hepatocellular carcinoma (HCC), the clinical
outcome is still unsatisfactory. Increased expression of human growth hormone (hGH) in …

In addition to being an important mediator of migration and invasion of tumor cells, β3
integrin can also enhance TGF-β1 signaling. However, it is not known whether β3 might …

Simple Summary Vessel co-option has been recognized as a mechanism associated with
resistance to anti-angiogenic treatment in colorectal cancer liver metastases (CRCLMs) …

Simple Summary Hepatocellular carcinoma (HCC) progression depends on two major
processes, tumor growth and invasion. The present study investigated how these events are …