The organs of vertebrate species display a wide variety of morphology. A remaining
challenge in evolutionary developmental biology is to elucidate how vertebrate lineages …

The regulatory architecture that controls developmental genes is often a collection of
enhancers that, in combination, generate a complex spatial and temporal pattern of …

Sonic Hedgehog (SHH) plays a fundamental role in numerous developmental processes
including morphogenesis of limbs, nervous system, and teeth. Using a Bayesian alignment …

Sonic Hedgehog (SHH) is one of the most intensively studied genes in developmental
biology. It is a highly conserved gene, found in species as diverse as arthropods and …

Embryonic development is an emergent process in which increasing complexity is
generated by sequential cellular interactions. Recently, it has become clear that such …

The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation
processes during vertebrate development. Numerous studies have suggested that the …

The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …

Morphogens act during development to provide graded spatial information that controls
patterning and cell lineage specification in the nervous system. The role of morphogen …

The origin and evolution of the complex regulatory landscapes of some vertebrate
developmental genes, often spanning hundreds of Kbp and including neighboring genes …

In zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)
is expressed in organiser regions such as the embryonic midline and the zona limitans …