Gene regulatory landscape of the sonic hedgehog locus in embryonic development
T Amano - Development, Growth & Differentiation, 2020 - Wiley Online Library
The organs of vertebrate species display a wide variety of morphology. A remaining
challenge in evolutionary developmental biology is to elucidate how vertebrate lineages …
challenge in evolutionary developmental biology is to elucidate how vertebrate lineages …
Long range regulation of the sonic hedgehog gene
E Anderson, RE Hill - Current Opinion in Genetics & Development, 2014 - Elsevier
The regulatory architecture that controls developmental genes is often a collection of
enhancers that, in combination, generate a complex spatial and temporal pattern of …
enhancers that, in combination, generate a complex spatial and temporal pattern of …
Phylogenetic footprinting reveals extensive conservation of Sonic Hedgehog (SHH) regulatory elements
Sonic Hedgehog (SHH) plays a fundamental role in numerous developmental processes
including morphogenesis of limbs, nervous system, and teeth. Using a Bayesian alignment …
including morphogenesis of limbs, nervous system, and teeth. Using a Bayesian alignment …
Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates
S Dorus, JR Anderson, EJ Vallender… - Human Molecular …, 2006 - academic.oup.com
Sonic Hedgehog (SHH) is one of the most intensively studied genes in developmental
biology. It is a highly conserved gene, found in species as diverse as arthropods and …
biology. It is a highly conserved gene, found in species as diverse as arthropods and …
Orchestrating ontogenesis: variations on a theme by sonic hedgehog
Embryonic development is an emergent process in which increasing complexity is
generated by sequential cellular interactions. Recently, it has become clear that such …
generated by sequential cellular interactions. Recently, it has become clear that such …
Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation
processes during vertebrate development. Numerous studies have suggested that the …
processes during vertebrate development. Numerous studies have suggested that the …
Sonic hedgehog signaling in limb development
C Tickle, M Towers - Frontiers in cell and developmental biology, 2017 - frontiersin.org
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
VH Sousa, G Fishell - Current opinion in genetics & development, 2010 - Elsevier
Morphogens act during development to provide graded spatial information that controls
patterning and cell lineage specification in the nervous system. The role of morphogen …
patterning and cell lineage specification in the nervous system. The role of morphogen …
Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties
The origin and evolution of the complex regulatory landscapes of some vertebrate
developmental genes, often spanning hundreds of Kbp and including neighboring genes …
developmental genes, often spanning hundreds of Kbp and including neighboring genes …
[HTML][HTML] Cooperation of sonic hedgehog enhancers in midline expression
R Ertzer, F Müller, Y Hadzhiev, S Rathnam… - Developmental …, 2007 - Elsevier
In zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)
is expressed in organiser regions such as the embryonic midline and the zona limitans …
is expressed in organiser regions such as the embryonic midline and the zona limitans …