Development of novel self‐assembled vaccines based on tumour‐specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via …

W Shi, Z Tong, S Chen, Q Qiu, J Zhou, H Qian - Immunology, 2023 - Wiley Online Library
Vaccines based on tumour‐specific antigens are a promising approach for immunotherapy.
However, the clinical efficacy of tumour‐specific antigens is still challenging. Twelve …

[HTML][HTML] Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective …

W Shi, Q Qiu, Z Feng, Z Tong, W Guo… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Considering the narrow immune response spectrum of a single epitope, and
the nanoparticles (NPs) as a novel adjuvant can achieve efficient delivery of antigenic …

Self-assembled peptide/polymer hybrid nanoplatform for cancer immunostimulating therapies

S Khazaei, R Varela-Calviño… - Drug Delivery and …, 2024 - Springer
Integrating peptide epitopes in self-assembling materials is a successful strategy to obtain
nanovaccines with high antigen density and improved efficacy. In this study, self-assembling …

Synthetic, Supramolecular, and Self‐Adjuvanting CD8+ T‐Cell Epitope Vaccine Increases the Therapeutic Antitumor Immunity

P Yang, H Song, Z Feng, C Wang… - Advanced …, 2019 - Wiley Online Library
Peptide vaccines are used in clinical cancer immunotherapy, however, they generally suffer
from suboptimal immunogenicity compared to live or inactive virus vector vaccines or …

Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8+ T cells

W Shi, Q Qiu, Z Tong, W Guo, F Zou, Z Feng… - European journal of …, 2020 - Elsevier
Researches on tumor-associated antigen have become a hot target in immunotherapy, but it
stagnated in the pre-clinical/clinical stages. Here, we developed a series of MAGE-A1 …

[HTML][HTML] Self-assembling, self-adjuvanting and fully synthetic peptide nanovaccine for cancer immunotherapy

H Song, Q Su, P Huang, C Zhang, W Wang - Smart Materials in Medicine, 2021 - Elsevier
Cancer vaccines designed to initiate or amplify tumor-specific T-cell responses have been
used as a key approach for effective cancer immunotherapy. Across the history of tumor …

[HTML][HTML] Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response

L Zhang, J Huang, X Chen, C Pan, Y He… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Cancer vaccines are a promising strategy for cancer immunotherapy. Cancer
vaccines elicits a specific cytotoxic immune response to tumor antigens. However, the …

Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine

TY Liu, WM Hussein, AK Giddam, Z Jia… - Journal of medicinal …, 2015 - ACS Publications
Vaccination can provide a safe alternative to chemotherapy by using the body's natural
defense mechanisms to create a potent immune response against tumor cells. Peptide …

Co-assembled and self-delivered epitope/CpG nanocomplex vaccine augments peptide immunogenicity for cancer immunotherapy

X Shi, H Song, C Wang, C Zhang, P Huang… - Chemical Engineering …, 2020 - Elsevier
Peptide vaccines are broadly used as alternatives to traditional vaccines for cancer
immunotherapy; however, the clinical translation of peptide vaccination is still limited by the …

Peptide‐based therapeutic cancer vaccine: current trends in clinical application

W Liu, H Tang, L Li, X Wang, Z Yu, J Li - Cell Proliferation, 2021 - Wiley Online Library
The peptide‐based therapeutic cancer vaccines have attracted enormous attention in recent
years as one of the effective treatments of tumour immunotherapy. Most of peptide‐based …