Considerations in glaucoma therapy: fixed combinations versus their component medications

EJ Higginbotham - Clinical Ophthalmology, 2010 - Taylor & Francis
Fixed combinations of medications that lower intraocular pressure (IOP) are increasingly
used in the treatment of glaucoma and ocular hypertension and offer several potential …

Fixed-combination intraocular pressure-lowering therapy for glaucoma and ocular hypertension: advantages in clinical practice

G Holló, F Topouzis, RD Fechtner - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: Several large, randomized, prospective clinical trials have demonstrated that
medical therapy to reduce intraocular pressure (IOP) delays the onset and decreases …

Current and emerging fixed combination therapies in glaucoma: a safety and tolerability review

AG Konstas, L Schmetterer, VP Costa… - Expert opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction Fixed dose combinations (FCs) represent a potentially valuable
treatment strategy in glaucoma management. Fixed combinations not only improve …

Fixed-combination and emerging glaucoma therapies

DF Woodward, J Chen - Expert Opinion on Emerging Drugs, 2007 - Taylor & Francis
Ocular hypotensive agents are the only approved pharmacotherapy for glaucoma. Despite
significant advances during the past two decades, a large proportion of glaucoma patients …

Use of fixed-dose combination drugs for the treatment of glaucoma

AS Khouri, T Realini, RD Fechtner - Drugs & aging, 2007 - Springer
Glaucoma is a leading cause of irreversible visual loss. This potentially blinding disease is a
progressive optic neuropathy associated with elevated intraocular pressure (IOP). Initial …

Intraocular pressure-lowering combination therapies with prostaglandin analogues

F Aptel, C Chiquet, JP Romanet - Drugs, 2012 - Springer
Intraocular pressure (IOP) reduction is currently the only therapeutic approach demonstrated
to preserve visual function in patients with glaucoma. The first line of glaucoma treatment …

Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis

JW Cheng, SW Cheng, LD Gao, GC Lu, RL Wei - 2012 - journals.plos.org
Background The first goal of medical therapy in glaucoma is to reduce intraocular pressure
(IOP), and the fixed-combination medications are needed to achieve sufficiently low target …

Clinical effectiveness of brinzolamide 1%–brimonidine 0.2% fixed combination for primary open-angle glaucoma and ocular hypertension

S Sharma, S Trikha, SA Perera, T Aung - Clinical Ophthalmology, 2015 - Taylor & Francis
The main first-line treatment strategy for glaucoma is to reduce intraocular pressure (IOP) by
topical ocular hypotensive medications, but many patients require multiple medications for …

Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle …

A García-López, JA Paczka, J Jiménez-Román… - BMC …, 2014 - Springer
Background Fixed-combination ocular hypotensives have multiple advantages, but triple-
therapy dorzolamide/brimonidine/timolol (dorz/brim/tim) is only available in Latin and South …

Achieving low target pressures with today's glaucoma medications

L Cantor - Survey of ophthalmology, 2003 - Elsevier
In the 21st century there are more highly effective medical management options for
glaucoma than there were in the 1980s and 1990s. In deciding among them, the clinician's …