Class D β-lactamase-mediated resistance to β-lactams has been increasingly reported
during the last decade. Those enzymes also known as oxacillinases or OXAs are widely …

Class D β-lactamases are composed of 14 families and the majority of the member enzymes
are included in the OXA family. The genes for class D β-lactamases are frequently identified …

The Class D β-lactamases have emerged as a prominent resistance mechanism against β-
lactam antibiotics that previously had efficacy against infections caused by pathogenic …

Class C β-lactamases or cephalosporinases can be classified into two functional groups (1,
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …

Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are enzymes of the utmost clinical
importance due to their ability to produce resistance to carbapenems, the antibiotics of last …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

Carbapenem resistance in Acinetobacter spp. is increasingly being associated with OXA-
type β-lactamases with weak hydrolytic activity against imipenem and meropenem. Such …

ABSTRACT A carbapenem-resistant Pseudomonas aeruginosa strain (PA41437)
susceptible to expanded-spectrum cephalosporins was recovered from several consecutive …

Early after the introduction of the first (narrow spectrum) penicillins into clinical use,
penicillinase-producing staphylococci replaced (worldwide) the previously susceptible …

Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are
increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins …