Epigenetic mechanisms integrate genetic and environmental causes of disease, but
comprehensive genome-wide analyses of epigenetic modifications have not yet …

Background Rheumatoid arthritis is a common autoimmune disorder influenced by both
genetic and environmental factors. Epigenome-wide association studies can identify …

Background A DNA methylation signature has been characterized that distinguishes
rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) from osteoarthritis (OA) FLS. The …

Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

Changes to the DNA methylome have been described in patients with rheumatoid arthritis
(RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte …

Stratifying patients on the basis of molecular signatures could facilitate development of
therapeutics that target pathways specific to a particular disease or tissue location. Previous …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …