To evaluate the frequency and the prognostic value of different mechanisms of drug
resistance in acute leukemias, we investigated the expression of mdr 1 by …

Drug resistance remains a major problem in the treatment of patients with acute myeloid
leukemia (AML). Expression of the MDR1 gene in leukemic cells was shown previously to …

Multidrug resistance (MDR) is a complex phenomenon that includes the expression of many
different genes regulating drug transport or metabolism, cellular repair or detoxification …

Multidrug resistance gene (mdr1) RNA levels were determined in 55, and P-glycoprotein
expression in 37 samples of peripheral leukemic cells from 17 patients with acute …

Drug resistance often results in failure of anticancer chemotherapy in leukemias. Several
mechanisms of drug resistance are known with multidrug resistance (MDR) being the best …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …

A semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to
investigate and compare transcription levels of the human multidrug resistance gene …

One important mechanism of drug resistance in acute leukemia is the overexpression of the
multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P …

The ability to recognize the acquisition of multidrug resistance (MDR) in leukemia patients
would improve our ability to predict the responsiveness of patients to chemotherapy. To …

Resistance to multiple chemotherapeutic agents has been related to the production of P-
glycoprotein, a trans-membrane drug efflux pump that is encoded by the multidrug …