Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes

T Bäcklund, E Palojoki, A Saraste, A Eriksson… - Diabetologia, 2004 - Springer
Aims/hypothesis Diabetes is known to reduce survival after myocardial infarction. Our aim
was to examine whether diabetes is associated with enhanced cardiomyocyte apoptosis …

Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus

R Badalzadeh, B Mokhtari, R Yavari - The Journal of Physiological …, 2015 - Springer
Ischemic heart disease is one of the major causes of death worldwide. Ischemia is a
condition in which blood flow of the myocardium declines, leading to cardiomyocyte death …

Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes

S Ares-Carrasco, B Picatoste… - American Journal …, 2009 - journals.physiology.org
The aim of this paper is to study the myocardial damage secondary to long-term
streptozotocin-induced type 1 diabetes mellitus (DM1). Normotensive and spontaneously …

The accelerated post‐infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin‐induced diabetic rat model

GY Song, YJ Wu, YJ Yang, JJ Li… - European journal of …, 2009 - Wiley Online Library
Aims The mechanism by which diabetes mellitus exacerbates myocardial injury and the
incidence of heart failure after acute myocardial infarction (AMI), remains unclear. We …

[HTML][HTML] Diabetes increases apoptosis and necrosis in both ischemic and nonischemic human myocardium: Role of caspases and poly–adenosine diphosphate …

MF Chowdhry, HA Vohra, M Galiñanes - The Journal of thoracic and …, 2007 - Elsevier
OBJECTIVES: Diabetes is an important predictor of morbidity and mortality after cardiac
surgery, but the reason is unclear. The aims of these studies, therefore, were to elucidate …

Mild type 2 diabetes mellitus reduces the susceptibility of the heart to ischemia/reperfusion injury: identification of underlying gene expression changes

S Korkmaz-Icöz, A Lehner, S Li, A Vater… - Journal of Diabetes …, 2015 - Wiley Online Library
Despite clinical studies indicating that diabetic hearts are more sensitive to
ischemia/reperfusion injury, experimental data is contradictory. Although mild diabetes prior …

Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents

B Rodrigues, KT Rosa, A Medeiros, BD Schaan… - Cardiovascular …, 2011 - Springer
Background Although clinical diabetes mellitus is obviously a high risk factor for myocardial
infarction (MI), in experimental studies disagreement exists about the sensitivity to ischemic …

Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin‐induced diabetic rats

WW Kuo, LC Chung, CT Liu, SP Wu… - … biochemistry and its …, 2009 - Wiley Online Library
Increased myocyte apoptosis in diabetic hearts has been previously reported. Therefore, the
purpose of this study was to evaluate the effects of insulin on cardiac apoptotic, hypertrophic …

Hyperglycaemia protects the heart after myocardial infarction: aspects of programmed cell survival and cell death

C Malfitano, TC Alba Loureiro… - European Journal of …, 2010 - Wiley Online Library
Aims Exposure to a high glucose medium or diabetes has been found to protect the heart
against ischaemia. The activation of antiapoptotic and proliferative factors seems to be …

Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats

E Palojoki, A Saraste, A Eriksson… - American Journal …, 2001 - journals.physiology.org
We investigated the role of cardiomyocyte apoptosis in the remodeling of the left ventricle
from 24 h to 12 wk after myocardial infarction in the rat. Infarct size planimetry, quantification …