BACKGROUND & AIMS: Virus-specific CD4+ T cells play a major role in hepatitis C virus
(HCV) infection. Viral clearance is associated with vigorous and multispecific CD4+ T cell …

Virus-specific CD4+ T cells play a major role in viral infections, such as hepatitis C virus
(HCV). Viral clearance is associated with vigorous and multi-specific CD4+ T-cell responses …

Hepatitis C virus (HCV)-specific CD4+ effector T cell responses are likely to play a key role
in the immunopathogenesis of HCV infection by promoting viral clearance and maintaining …

CD4 T‐cell function is crucial for the eradication of HCV, and insufficient function is observed
in chronic carriers. The monitoring of T‐cell responses is complicated by the scarcity of …

Human and animal model evidence suggests that CD4+ T cells play a critical role in the
control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the …

Background. Human immunodeficiency virus (HIV) coinfection and low peripheral blood
CD4+ T cell counts are associated with increased hepatitis C liver disease. Methods …

Abstract Virus-specific CD4+ T-cell response at the site of inflammation is believed to play a
decisive role for the course of viral disease. In hepatitis C virus (HCV) infection, the majority …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

Hepatitis C virus (HCV) infection is a major cause of liver damage, with virus-induced end-
stage disease such as liver cirrhosis and hepatocellular carcinoma resulting in a high rate of …

Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific
CD4+ T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-γ) …