Commentary on: Chen S, Lyu X, Hong W, Zhang D, Zhang Y, Yang D, et al Bilateral Inferior
Petrosal Sinus Sampling Without Lateralization Is Less Accurate for the Diagnosis of …

Background: Bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold
standard for diagnosing ACTH-dependent Cushing's syndrome caused by ACTH producing …

Context Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing's disease (CD)
when dexamethasone-suppression and CRH tests, and pituitary magnetic resonance …

The diagnostic differentiation between Cushing's disease and ectopic adrenocorticotropic
hormone (ACTH) syndrome is frequently difficult, because dynamic biochemical testing …

Abstract Cushing's disease (CD), which manifests as excess cortisol secretion, is caused by
adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas. Such adenomas are …

The majority of patients with Cushing's disease can be cured by transsphenoidal
microsurgery; however, precise localization of the pituitary source of ACTH is not always …

In patients with ACTH-dependent Cushing's syndrome (CS), the differentiation between
Cushing's disease (CD) and ectopic ACTH secretion (EAS) can often be challenging. The …

Objective Inferior petrosal sinus sampling (IPSS) distinguishes pituitary‐dependent
Cushing's disease (CD) from ectopic ACTH syndrome with a high degree of certainty, but …

OBJECTIVE: Identifying the cause of Cushing's syndrome (CS) is a perplexing issue.
Bilateral inferior petrosal sinuses sampling (BIPSS) is an invasive and elaborate but …

Context During bilateral inferior petrosal sinus sampling (BIPSS), the side-to-side
adrenocorticotropic hormone (ACTH) ratio, referred to as sampling lateralization, was used …