In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding
drug-drug interactions and for drug development. However, the profile of the inhibitory …

Esterified drugs such as imidapril, derapril, and oxybutynin hydrolyzed by carboxylesterase
1 (CES1) are extensively used in clinical practice. The kinetics using the CES1 substrates …

Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients …

Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11) …

Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

Carboxylesterase (CES) plays an important role in the hydrolysis metabolism of ester–type
drugs and prodrugs. In this study, we investigated the change in the hydrolysis rate of hCE1 …

Abstract Carboxylesterase (CES) 1, CES2, and arylacetamide deacetylase (AADAC) are the
major drug hydrolases in humans, and they have different substrate preferences. Because …

Several mouse carboxylesterase (CES) isozymes have been identified, but information
about their roles in drug metabolism is limited. In this study, we purified and characterized a …

Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE,
HU3) are a serine esterase involved in both drug metabolism and activation. Although both …