Polymerization of sickle cell hemoglobin (HbS) in deoxy state is one of the basic events in
the pathophysiology of sickle cell anemia. For insight into the polymerization process, we …

The polymerization of sickle hemoglobin involves the assembly of 14 stranded fibers, which
are found in dense multibranched arrays (Briehl, 1995; White & Heagan, 1970) called …

Sickle cell anemia is associated with the mutant hemoglobin HbS, which forms polymers in
red blood cells of patients. The growth rate of the polymers is several micrometers per …

The primary pathogenic event of sickle cell anemia is the polymerization of the mutant
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …

The measurement of polymer growth is an essential element in characterization of
assembly. We have developed a precise method of measuring the growth of sickle …

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of
babies born each year worldwide. Its primary pathogenic event is the polymerization of a …

A double nucleation mechanism for the polymerization of sickle hemoglobin is described.
The mechanism accounts for all of the major kinetic observations: the appearance of a …

In search of novel control parameters for the polymerization of sickle cell hemoglobin (HbS),
the primary pathogenic event of sickle cell anemia, we explore the role of free heme, which …

Sickle cell anaemia is associated with a mutant haemoglobin, HbS, which forms polymers in
the red blood cells of patients. The primary role of the HbS polymerization for the …

Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …