Introduction Although nicotine is the primary reinforcing constituent in cigarettes, there is
evidence that other constituents in cigarette smoke may interact with nicotine to reinforce …

Tobacco smoking has been shown to be quite addictive in people. However, nicotine itself is
a weak reinforcer compared to other commonly abused drugs, leading speculation that other …

Although nicotine is generally considered to be the main psychoactive component of
tobacco, growing evidence highlights the importance of nonnicotine compounds in smoking …

Tobacco use has one of the highest rates of addiction of any abused drug. Paradoxically, in
animal models, nicotine appears to be a weak reinforcer. We report here that the inhibition of …

Introduction: Rodent studies suggest that nicotine metabolites and minor tobacco alkaloids
such as nornicotine and cotinine may promote cigarette smoking by enhancing nicotine …

Our current study aims to evaluate the mechanisms of tranylcypromine (TCP)-mediated
enhancement of nicotine self-administration. We replicated our previous findings which …

Nicotine is only mildly rewarding, but after becoming dependent, it is difficult to quit smoking.
The goal of these studies was to determine if low-nicotine cigarettes are less likely to cause …

Rationale Partial agonists and antagonists of addictive drugs have been useful in the
treatment of dependence. Objective The purpose of this study is to determine whether …

Rationale The mechanisms mediating tobacco addiction remain elusive. Nicotine, the
psychoactive component in tobacco, is generally believed to be the main cause of reward …

Rationale Nicotine has two effects on reinforcement in traditional self-administration
paradigms. It serves as a primary reinforcer by increasing the probability of behaviors that …