The dense desmoplastic and fibrotic stroma is a characteristic feature of pancreatic ductal
adenocarcinoma (PDAC), regulating disease progression, metastasis and response to …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant
malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC …

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of
pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic …

Cancer‐associated fibroblasts (CAF s) are considered the most abundant type of stromal
cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour …

Objective We investigated how pancreatic cancer developed resistance to focal adhesion
kinase (FAK) inhibition over time. Design Pancreatic ductal adenocarcinoma (PDAC) …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer in large part due to late
diagnosis and a lack of effective screening tests. In spite of recent progress in imaging …

Current therapies for pancreatic ductal adenocarcinoma (PDA) target individual tumor cells.
Focal adhesion kinase (FAK) is activated in PDA, and levels are inversely associated with …

Pancreatic cancer, a disease with extremely poor prognosis, has been notoriously resistant
to virtually all forms of treatment. The dynamic crosstalk that occurs between tumour cells …

The vast stroma/desmoplasia produced by cancer-associated fibroblasts (CAFs) is clinically
characteristic of pancreatic ductal adenocarcinoma (PDAC) and contributes to poor …

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with a 5 year survival rate
of less than 8%, and is predicted to become the second leading cause of cancer-related …