[HTML][HTML] PNPLA3 I148M polymorphism and progressive liver disease

P Dongiovanni, B Donati, R Fares… - World journal of …, 2013 - ncbi.nlm.nih.gov
Abstract The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like
phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is …

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

N Salari, N Darvishi, K Mansouri, H Ghasemi… - BMC endocrine …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to
be the leading cause of chronic liver disease worldwide. This study aims to systematically …

[PDF][PDF] The association of genetic variability in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver …

Y Rotman, C Koh, JM Zmuda, DE Kleiner… - …, 2010 - Wiley Online Library
Genome‐wide association studies identified single‐nucleotide polymorphisms (SNPs) that
are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting …

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

S Romeo, J Kozlitina, C Xing, A Pertsemlidis, D Cox… - Nature …, 2008 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown
etiology that varies in prevalence among ancestry groups. To identify genetic variants …

[PDF][PDF] Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

F Stickel, S Buch, K Lau, HM zu Schwabedissen… - …, 2011 - Wiley Online Library
A recent genome‐wide study revealed an association between variation in the PNPLA3
gene and liver fat content. In addition, the PNPLA3 single‐nucleotide polymorphism …

[HTML][HTML] Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)

NS Choudhary, A Duseja - Translational gastroenterology and …, 2021 - ncbi.nlm.nih.gov
Inter-individual and inter-ethnic differences and difference in the severity and progression of
liver disease among patients with non-alcoholic fatty liver disease (NAFLD) and alcoholic …

[PDF][PDF] Insulin resistance exacerbates genetic predisposition to nonalcoholic fatty liver disease in individuals without diabetes

L Barata, MF Feitosa, LF Bielak… - Hepatology …, 2019 - Wiley Online Library
The accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy
alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a …

Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population

X Wang, Z Liu, K Wang, Z Wang, X Sun, L Zhong… - Frontiers in …, 2016 - frontiersin.org
Recent genome-wide association studies have identified that variants in or near PNPLA3,
NCAN, GCKR, LYPLAL1, and TM6SF2 are significantly associated with non-alcoholic fatty …

Additive effects of PNPLA3 and TM6SF2 on the histological severity of non‐alcoholic fatty liver disease

BK Koo, SK Joo, D Kim, JM Bae, JH Park… - Journal of …, 2018 - Wiley Online Library
Abstract Background and Aim We investigated the effects of PNPLA3 rs738409, TM6SF2
rs58542926, and MBOAT7‐TMC4 rs641738 variants on metabolic phenotypes and their …

[PDF][PDF] The expression of PNPLA3 polymorphism could be the key for severe liver disease in NAFLD in Hispanic population

LA Martínez, E Larrieta, JJ Calva… - Annals of …, 2018 - medigraphic.com
ABSTRACT Background. Background. Nonalcoholic fatty liver disease (NAFLD)
encompasses: fatty liver (SS), steatohepatitis (NASH) with or without fibrosis and cirrhosis …