p19ARF has been implicated as a key regulator of p53 stability and activation. While
numerous stresses activate the p53 growth arrest pathway, those requiring p19ARF remain …

Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …

The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …

Ionizing radiation leads to rapid stabilization and activation of the p53 tumor suppressor.
Previous reports demonstrate that murine p19ARF cooperates with p53 in the cellular …

p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …

Normal healthy cells possess safeguard mechanisms that sense oncogenic signals and
trigger anti-tumorigenic responses that limit the proliferative potential of cells harbouring …

p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism.
p19ARF was found to complex with transcription factors E2F1,-2, and-3. Levels of …

The p53-mediated pathway cell cycle arrest and apoptosis is central to cancer and an
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …

Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …

Unknown mechanisms govern degradation of the p19Arf tumor suppressor, an activator of
p53 and inhibitor of ribosomal RNA processing. Kinetic metabolic labeling of cells with [3H] …