Most solid tumors possess unique pathophysiological characteristics that are not observed
in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature …

Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the
discovery and synthesis of hundreds of thousands of anticancer compounds targeting …

Blood vessels in tumors are different to normal blood vessels because they have abnormal
architectures and impaired functional regulation. We have studied these abnormalities, in …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors related to their anatomical and pathophysiological differences from normal tissues …

In this review, I have discussed various issues of the cancer drug targeting primarily related
to the EPR (enhanced permeability and retention) effect, which utilized nanomedicine or …

The enhanced permeability and retention (EPR) effect of solid tumors as seen with
nanomedicines and macromolecular drugs is well known. However, many researchers …

Most solid tumors are known to exhibit highly enhanced vascular permeability, similar to or
more than the inflammatory tissues. Common denominators affecting both cancer and …

This Special Issue on the enhanced permeability and retention (EPR) effect commemorates
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …