Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

C Mc Guire, M Prinz, R Beyaert, G van Loo - Trends in molecular medicine, 2013 - cell.com
The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation
of immune and inflammatory responses and has been implicated in the pathogenesis of …

Nuclear factor κB (NF-κB)–mediated inflammation in multiple sclerosis

Y Zhou, C Cui, X Ma, W Luo, SG Zheng… - Frontiers in …, 2020 - frontiersin.org
The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of
biological processes, including inflammation, cell proliferation, differentiation, and apoptosis …

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

Y Yue, S Stone, W Lin - Neural regeneration research, 2018 - journals.lww.com
The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic …

NF-κB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications

SM Leibowitz, J Yan - Frontiers in molecular neuroscience, 2016 - frontiersin.org
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways
are involved in cell immune responses, apoptosis and infections. In multiple sclerosis (MS) …

NF-κB, a potential therapeutic target for the treatment of multiple sclerosis

J Yan, JM Greer - CNS & neurological Disorders-Drug targets …, 2008 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) that afflicts over 2 million people worldwide. On the basis of the temporal …

Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation

G Ellrichmann, J Thöne, DH Lee, RA Rupec… - Journal of …, 2012 - Springer
Abstract The NF-κB/REL-family of transcription factors plays a central role in coordinating the
expression of a wide variety of genes controlling immune responses including autoimmunity …

NF-κB activation protects oligodendrocytes against inflammation

S Stone, S Jamison, Y Yue, W Durose… - Journal of …, 2017 - Soc Neuroscience
NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of …

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

G van Loo, R De Lorenzi, H Schmidt, M Huth… - Nature …, 2006 - nature.com
Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …

NF-κB as a therapeutic target in neurodegenerative diseases

S Camandola, MP Mattson - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
NF-κB is a transcription factor that regulates numerous physiological functions, and that is
involved in the pathogenesis of various diseases. In the nervous system there is evidence …

Cellular specificity of NF-κB function in the nervous system

EC Dresselhaus, MK Meffert - Frontiers in immunology, 2019 - frontiersin.org
Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key
functions in a wide array of biological systems. While the role of NF-κB in processes, such as …