There is now general agreement that osteoarthritis (OA) involves all structures in the affected
joint, culminating in the degradation of the articular cartilage. It is appropriate to focus …

Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

The articular cartilage and the subchondral bone form a biocomposite that is uniquely
adapted to the transfer of loads across the diarthrodial joint. During the evolution of the …

This review focuses on recent findings in pathobiology of osteoarthritis (OA). The progress in
this field will be illustrated based on three questions; 1. What factors maintain or alter the …

The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by
biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Although cartilage degeneration characterizes human osteoarthritis (OA), changes also
involve the participation of the synovial membrane and the subchondral bone. In this review …

Osteoarthritis (OA) is a slowly progressive degenerative joint disorder characterized by
cartilage damage, changes in periarticular bone including osteophyte formation and a …

Osteoarthritis is the most prevalent degenerative joint disease and one of the leading
causes of physical impairment in the world's aging population. The human lifespan has …