In the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis,
spondyloarthritis, osteoarthritis, osteoporosis, alterations in osteoblast growth, differentiation …

In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in
response to alterations in the environment owing to mechanical injury and inflammation …

Osteocalcin (OC), which is a marker of the mature osteoblasts, can also be found in
posthypertrophic chondrocytes of the epiphyseal growth plate, but not in chondrocytes of the …

Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large
population worldwide and for which there is no definitive cure. This review provides critical …

Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …

The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical,
biochemical, and genetic factors that contribute to the imbalance in the synthesis and …

■ Despite the fact that presumably a high variety of different phenomena contribute to the
pathogenesis of OA, premature aging of the chondrocytes and the matrix presumably plays …

The cartilage damage which characterizes osteoarthritis is often accompanied by bone
lesions. Joint integrity results from the balance in the physiological interactions between …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Osteoarthritis (OA) is a disease of high prevalence that produces substantial morbidity and is
a leading cause of physical and psychological disability and expense, including time lost …