Objective To explore the effects of tumor suppressor p14ARF on chemosensitivity of human
osteosarcoma U2OS cells to cisplatin and elucidate its molecular mechanism. Methods …

Objective To study effect of tumor suppressor p14ARF on cisplatin-induced apoptosis in
human osteosarcoma cells with its molecular mechanisms to provide evidences for …

The tumor suppressor p14ARF, encoded by the INK4a/ARF locus, is often disrupted in
human cancers. p14ARF triggers cell cycle arrest and sensitizes cells to apoptosis in the …

Tumor suppressor ARF can induce cell cycle arrest or apoptosis by activating p53. In order
to explore the molecular mechanism of the induction of apoptosis by p14 ARF, a human …

The INK4A/ARF locus on chromosome 9 is a tumor suppressor gene frequently mutated in
human cancers. In order to study the effects of p14ARF expression in tumor cells, we …

Objective To investigate the synergistic antitumor effects of combined use of p14ARF gene
and 5-fluorouracil (5-Fu) in pancreatic cancer. Methods A human pancreatic cancer cell line …

The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …

p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …

p14ARF tumor suppressor protein regulates p53 by interfering with mdm2–p53 interaction.
p14ARF is activated in response to oncogenic stimuli but little is known of the responses of …

Background During cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and
generates p20BAP31, which has been shown to induce an apoptotic pathway between the …