BACKGROUND: The aim of this study was to determine whether neocortical long-term
potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid …

Age-dependent alterations in the induction of long-term potentiation (LTP) are well
documented, providing a likely neural basis for memory decline associated with aging …

To characterize the mechanisms underlying region-and age-dependent hippocampal
synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing …

Background: Mechanisms of cortical plasticity have been recently investigated in
Alzheimer's disease (AD) patients with transcranial magnetic stimulation protocols showing …

In animal models of Alzheimer's disease (AD), amyloid-β fragments interfere with
mechanisms of cortical plasticity such as long-term potentiation (LTP) and long-term …

Alzheimer's disease (AD) is a consequence of degenerative brain pathology with amyloid
plaque deposition and neurofibrillary tangle formation. These distinct aspects of AD …

Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …

The N-methyl-D-aspartate receptor (NMDAR) is a critical molecule for synaptic plasticity and
cognitive function. Impaired synaptic plasticity is thought to contribute to the cognitive …

Background Alzheimer's disease (AD) is characterized by a primary impairment of long-term
declarative memory caused by deposition of misfolded protein aggregates. Experimental …

Objective Alzheimer's disease (AD) is considered an age‐related disorder. However, it is
unclear whether AD induces the same pathological and neurophysiological modifications in …