Abnormal processing of amyloid precursor protein (APP), in particular the generation of β-
amyloid (Aβ) peptides, has been implicated in the pathogenesis of Alzheimer's disease. This …

Progressive memory loss and cognitive dysfunction are the hallmark clinical features of
Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related …

Understanding the physiology of learning and memory is one of the great challenges of
neuroscience. The discovery in recent years of long-term potentiation (LTP) of synaptic …

Alzheimer's disease (AD) is one of the most common causes of dementia. Although the
exact mechanisms of AD are not entirely clear, the impairment in adult hippocampal …

LTP is a form of activity-dependent synaptic plasticity that has been investigated mainly in
the hippocampus. It is considered likely that similar mechanisms may also account for …

Alzheimer's disease (AD) is characterized by accumulation of amyloid-β peptide (Aβ) in the
brain regions that subserve memory and cognition. The amylin receptor is a potential target …

Mounting evidence indicates that impairments of synaptic efficacy and/or plasticity may be a
key step in the development of Alzheimer's disease (AD) pathophysiology. Among the 2 …

Alzheimer's disease (AD) is a neurodegenerative process characterized by progressive
neuronal degeneration, reduced levels of neurotransmitters, and altered forms of synaptic …

Shankar, Subbakrishna, Timothy J. Teyler, and Norman Robbins. Aging differentially alters
forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 79: 334–341 …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous
mouse models have been generated. In both AD patients and mouse models, there is …