Thermoreversible Poly(ethylene glycol)-g-Chitosan Hydrogel as a Therapeutic T Lymphocyte Depot for Localized Glioblastoma Immunotherapy
The outcome for glioblastoma patients remains dismal for its invariably recrudesces within 2
cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual …
cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual …
In situ targeting nanoparticles-hydrogel hybrid system for combined chemo-immunotherapy of glioma
X Wang, L Ye, W He, C Teng, S Sun, H Lu, S Li… - Journal of Controlled …, 2022 - Elsevier
It is well known that glioma is currently the most malignant brain tumor. Because of the
existence of blood-brain barrier (BBB) and tumor cell heterogeneity, systemic chemotherapy …
existence of blood-brain barrier (BBB) and tumor cell heterogeneity, systemic chemotherapy …
Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies
The success of promising anti-cancer adoptive cell therapies relies on the abilities of the
perfused CD8+ T lymphocytes to gain access to and persist within the tumor …
perfused CD8+ T lymphocytes to gain access to and persist within the tumor …
Combination of hyaluronic acid conjugates with immunogenic cell death inducer and CpG for glioblastoma local chemo-immunotherapy elicits an immune response …
G Catania, G Rodella, K Vanvarenberg, V Préat… - Biomaterials, 2023 - Elsevier
The efficacy of standard glioblastoma (GBM) treatments has been limited due to the highly
immunosuppressive tumor immune microenvironment, interpatient tumor heterogenicity and …
immunosuppressive tumor immune microenvironment, interpatient tumor heterogenicity and …
Combination therapy of surgical tumor resection with implantation of a hydrogel containing camptothecin-loaded poly (lactic-co-glycolic acid) microspheres in a C6 rat …
T Ozeki, D Kaneko, K Hashizawa, Y Imai… - Biological and …, 2012 - jstage.jst.go.jp
We have developed a drug-loaded poly (lactic-co-glycolic acid)(PLGA) microsphere-
containing thermoreversible gelation polymer (TGP)(drug/PLGA/TGP) formulation as a novel …
containing thermoreversible gelation polymer (TGP)(drug/PLGA/TGP) formulation as a novel …
Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma
The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
Self-Cross-Linked Chitosan/Albumin-Bound Nanoparticle Hydrogel for Inhibition of Postsurgery Malignant Glioma Recurrence
W Long, S Li, Y Yang, A Chen, M Xu… - … Applied Materials & …, 2023 - ACS Publications
The development of chemoimmunotherapy with reduced systemic toxicity using local
formulations is an effective strategy for combating tumor recurrence. Herein, we reported a …
formulations is an effective strategy for combating tumor recurrence. Herein, we reported a …
1, 3β-Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy
Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature
and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery …
and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery …
Post-resection treatment of glioblastoma with an injectable nanomedicine-loaded photopolymerizable hydrogel induces long-term survival
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite
available therapeutic options, the prognosis for patients with GBM remains very poor. We …
available therapeutic options, the prognosis for patients with GBM remains very poor. We …
[HTML][HTML] Temperature and pH-responsive in situ hydrogels of gelatin derivatives to prevent the reoccurrence of brain tumor
Glioblastoma multiforme (GBM) is a grade IV malignant brain tumor with a median survival
time of approximately 12–16 months. Because of its highly aggressive and heterogeneous …
time of approximately 12–16 months. Because of its highly aggressive and heterogeneous …