The G protein-coupled receptors (GPCRs) play a pivotal role in numerous biological
processes as crucial cell membrane receptors. However, the dynamic mechanisms …

Agonists selectively targeting cannabinoid receptor-like G-protein-coupled receptor (GPCR)
GPR119 hold promise for treating metabolic disorders while avoiding unwanted side effects …

Within over 800 members of G-protein-coupled receptors, there are numerous orphan
receptors whose endogenous ligands are largely unknown, providing many opportunities for …

G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors
that have diverse roles in physiology and are major drug targets. GPCRs transduce an …

Class-A G protein-coupled receptors (GPCRs) are known to homo-dimerize in the
membrane. Yet, methods to characterize the structure of GPCR dimer in the native …

G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …

G protein coupled receptors (GPCRs) are a large eukaryotic protein family of
transmembrane receptors that react to a signal coming from the extracellular environment to …

Highlights•Both GPCRs and G proteins sample multiple conformations in their basal
states.•Stabilizing a fully active state of several GPCRs requires agonist and G …

GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a
possible target for the treatment of type 2 diabetes. In this work, we conducted a bidirectional …

Unstructured regions in functional proteins have gained attention in recent years due to
advancements in informatics tools and biophysical methods. G protein-coupled receptors …