Recent studies have shown a significant increase in plasma digoxin concentration during
verapamil treatment. This phenomenon has been attributed in part to reduced renal …

To explore a possible interaction between digoxin and verapamil, a single‐dose kinetic
study of digoxin was performed and then repeated after 10 days of verapamil treatment in …

The interaction between digoxin and verapamil was studied in six patients (mean age±SD,
61±5 years) with chronic atrial fibrillation. The effects of adding verapamil (240 mg/day) on …

Verapamil and digoxin are often used in combination and clinical experience suggests that
verapamil may increase digoxin toxicity. We have explored the effects of verapamil upon …

The effects on the steady‐state digoxin pharmacokinetics of verapamil (240 mg/day) and a
new dihydropyridine calcium channel blocker, isradipine (15 mg/day), were compared …

Conflicting conclusions have been reported about interaction of calcium channel blockers
with digoxin. The effects of verapamil (240 mg/day) and a new dihydropyridine calcium …

Several investigators have independently discovered that the calcium antagonist, verapamil,
causes a 60–80% increase in plasma digoxin. Pharmacokinetic studies indicate, that the …

Single-dose investigations in healthy subjects have demonstrated substantial impairment of
renal and extrarenal clearance of digoxin during coadministration of verapamil. A …

Recently quinidine and verapamil have been reported to cause toxic accumulation of
digoxin due to mainly decrease in the renal secretion of the cardiac glycoside. Because …

Digoxin has been associated with a variety of drug interactions. Studies in our laboratory
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …