The pharmacokinetics of digoxin was studied in 11 subjects before and during quinidine
treatment. Renal clearances of digoxin and creatinine were calculated from plasma …

Several recent reports have shown that plasma concentrations of digoxin increase when
quinidine is administered along with digoxin; the present study was designed to explore the …

Digoxin was infused intravenously 27.5 μg/min. to guinea pigs. By means of the ECG doses
of digoxin needed to cause ventricular extrasystoles (VES), ventricular fibrillation (VF), and …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

There is a pharmacokinetic interaction between digoxin and diazepam that increases the
elimination half-life of digoxin. It may be due to a reduction of digoxin tissue concentrations …

To determine whether nifedipine or diltiazem affect digoxin kinetics, glycoside plasma
concentrations and renal excretion were measured before and during dosing in 23 patients …

A kinetic and hemodynamic study of digoxin was performed in six healthy subjects and
similar studies were performed during digoxin with spironolactone and with triamterene …

Digoxin and Verapamil may often be used in association in heart diseases; we tested
whether this coadministration increases digitalis activity. Ten patients with failing heart were …

Glycoside concentrations in plasma and various tissues of dogs were determined after a
single and repeated intravenous administration of tritium-labeled digoxin and [beta] …

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …