The influence of a single low dose of verapamil (80 mg) on the serum levels of digoxin
(single dose of 0.5 mg) was studied in 6 patients with hepatic cirrhosis and in 6 healthy …

Abstract 1 Twenty-nine dogs were given digoxin (0.25 mg) by mouth twice daily for eight
days. Some of them (group 1) also received diuretics and others (group 2) a …

The effects of digoxin on electrophysiologic properties were evaluated in isolated perfused
cardiac tissue. In canine Purkinje fiber (PF)-ventricular muscle (VM) preparations, control …

Biological serum halt-life, relative volume of distribution and digoxin clearance following a
single oral dose of digoxin with diltiazem or nifedipine were evaluated. Blood serum digoxin …

It is now well established that administration of the cardiac anti-arrhythmic drug, quinidine,
can produce significantly elevated plasma levels of simultaneously administered digoxin in …

The pharmacokinetics of digoxin were studied before and after a 2 week course of diltiazem,
30 mg four times daily, in 7 healthy volunteers. Each subject received an IV dose of digoxin …

Pharmacologic response to digitalis appears to be diminished in the reserpine-pretreated
mammalian heart. A lower myocardial concentration of digitalis was postulated to account …

To evaluate a possible effect of diltiazem hydrochloride (DTZ) on digoxin (DX) kinetics, we
performed a study in which a single oral dose of DX (0.5 or 0.75 mg) was given with and …

The purpose of this study was to determine if there is a linear relationship between oral
doses of digoxin and various measurements of steady-state digoxin plasma concentration …

Abstract 1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was
determined indirectly at various times after its administration to eight conscious dogs by …