Abstract 1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was
determined indirectly at various times after its administration to eight conscious dogs by …

The chronotropic and inotropic effects as well as the tissue levels of digoxin and
methyldigoxin were studied in isolated guinea pig atria. Higher concentrations of …

Abstract 1 The time course of myocardial uptake of digoxin, increase in contractility and
changes in myocardial potassium concentration was studied for 90 min following an …

Tritiated (12α‐3H) digoxin (0· 05 mg/kg body weight) was administered intravenously to
conscious dogs with circulatory volume overload induced by previous creation of aorto …

Digoxin serum and urine levels were determined by radioimmunoassay in 6 subjects (4
patients with heart disease and 2 volunteers without heart disease) who had been …

The effects of equihypotensive doses of nicorandil and verapamil on plasma digoxin
concentrations have been assessed in rats and dogs. In a single digoxin dose study, digoxin …

The effect of hypoxia on digoxin pharmacokinetics, myocardial digoxin uptake and levels of
plasma catecholamines in dogs was studied to clarify the mechanism of enhanced …

1 This study was designed to evaluate pharmacokinetically the digoxin‐quinidine interaction
in patients with atrial fibrillation. 2 Five patients on maintenance digoxin therapy were given …

Six subjects were evaluated for the effect of quinine, the 1‐isomer of quinidine, on digoxin
pharmacokinetics. A 1.0‐mg intravenous digoxin dose was given before and during quinine …

Methods Bound and unbound digoxin plasma levels were determined in-vitro, in a control
human plasma containing 2.5 x 1CW M (2 ng ml-1) of digoxin to which 1 and 3 pg ml-1 were …