This substantially updated edition presents fundamental principles and concepts behind the
various types of toxicological studies, and explains how to design and conduct studies and …

The evolution of toxicology testing finds its impetus in the continuing growth of the chemical
and pharmaceutical industries, as well as the awareness of public health initiatives, needs …

Each year thousands of chemi cals undergo rigorous testing designed to evaluate their
poten tial toxicity. Almost all of the tests take place in animals: the reactions of rats, rabbits …

Developments in cell culture and in bioanalytical and computer technology have resulted in
the rapid proliferation of new procedures for use in the hazard evaluation of chemicals (1) …

Prepared at the request of the National Toxicology Program, this landmark report reveals
that many chemicals used in pesticides, cosmetics, drugs, food, and commerce have not …

Over the past year, a series on commentaries have appeared in the Toxicological Sciences
Forum Series related to the 2007 National Research Council (NRC) publication, Toxicity …

The report by the US National Research Council entitled Toxicity Testing in the 21st Century:
A Vision and a Strategy (National Research Council, 2007) lays out a bold vision for the …

Toxicity testing is paramount in the screening of newly developed drugs before it can be
used on humans. The essence of toxicity testing is not just to check how safe a test …

This is the report of the fifth of a series of workshops organised by the European Centre for
the Validation of Alternative Methods (ECV AM). ECV AM's main goal, as defined in 1993 by …

The landmark publication by the National Research Council putting forward a vision of a
toxicology for the 21st century in 2007 has created an atmosphere of departure in our field …