Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells
Recently, we developed a new paradigm in macromolecular therapeutics that avoids the
use of low molecular weight drugs. The activity of the “drug-free macromolecular …
use of low molecular weight drugs. The activity of the “drug-free macromolecular …
Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells
A new drug-free nanotherapeutic approach for B-cell malignancies was developed.
Exposure of B-cells to an anti-CD20 Fab'-morpholino oligonucleotide1 (MORF1) conjugate …
Exposure of B-cells to an anti-CD20 Fab'-morpholino oligonucleotide1 (MORF1) conjugate …
Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment …
Drug-free macromolecular therapeutics (DFMT) is a new paradigm for the treatment of B cell
malignancies. Apoptosis is initiated by the biorecognition of complementary oligonucleotide …
malignancies. Apoptosis is initiated by the biorecognition of complementary oligonucleotide …
Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo
MT Gambles, J Li, DC Radford, D Sborov… - Journal of Controlled …, 2022 - Elsevier
Abstract Drug-Free Macromolecular Therapeutics (DFMT) is a new paradigm in
macromolecular therapeutics that induces apoptosis in target cells by crosslinking receptors …
macromolecular therapeutics that induces apoptosis in target cells by crosslinking receptors …
Biorecognition: A key to drug-free macromolecular therapeutics
This review highlights a new paradigm in macromolecular nanomedicine–drug-free
macromolecular therapeutics (DFMT). The effectiveness of the new system is based on …
macromolecular therapeutics (DFMT). The effectiveness of the new system is based on …
Cell Surface Self-Assembly of Hybrid Nanoconjugates via Oligonucleotide Hybridization Induces Apoptosis
Hybrid nanomaterials composed of synthetic and biological building blocks possess high
potential for the design of nanomedicines. The use of self-assembling nanomaterials as “bio …
potential for the design of nanomedicines. The use of self-assembling nanomaterials as “bio …
Human Serum Albumin‐Based Drug‐Free Macromolecular Therapeutics: Apoptosis Induction by Coiled‐Coil‐Mediated Cross‐Linking of CD20 Antigens on …
A therapeutic platform—drug‐free macromolecular therapeutics (DFMT)—that induces
apoptosis in B cells by cross‐linking of CD20 receptors, without the need for low molecular …
apoptosis in B cells by cross‐linking of CD20 receptors, without the need for low molecular …
Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or …
J Li, MT Gambles, B Jones, JA Williams… - Drug Delivery and …, 2024 - Springer
This study explores the efficacy of human serum albumin (HSA)-based Drug-Free
Macromolecular Therapeutics (DFMT) in treating Chronic Lymphocytic Leukemia (CLL), a …
Macromolecular Therapeutics (DFMT) in treating Chronic Lymphocytic Leukemia (CLL), a …
Drug-free macromolecular therapeutics–a new paradigm in polymeric nanomedicines
This review highlights a unique research area in polymer-based nanomedicine designs.
Drug-free macromolecular therapeutics induce apoptosis of malignant cells by the …
Drug-free macromolecular therapeutics induce apoptosis of malignant cells by the …
[HTML][HTML] Drug-free macromolecular therapeutics: Induction of apoptosis by coiled-coil mediated crosslinking of antigens on cell surface
K Wu, J Liu, RN Johnson, J Yang… - … Chemie (International ed …, 2010 - ncbi.nlm.nih.gov
A new paradigm was designed for apoptosis induction mediated by the biorecognition of
coiledcoil motifs at the Raji B cell surface. The heterodimerization of complementary …
coiledcoil motifs at the Raji B cell surface. The heterodimerization of complementary …