Sickle cell trait occurs in approximately 300 million people worldwide, with the highest
prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign …

Sickle cell disease (SCD) is an autosomal recessive genetic condition that alters the shape
and function of the hemoglobin molecule in red blood cells. While the overall survival rate …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Background: Although sickle cell trait (SCT) is largely a benign carrier state, it may increase
risk for certain clinical outcomes. Purpose: To evaluate associations between SCT and …

Sickle Cell Trait - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe
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Objectives: Identify the epidemiology of sickle cell disease. Describe the different types of
sickle cell crises. Review the treatment and management options available for sickle cell …

We have collected steady-state laboratory data for over 2600 patients, age 2 years and over,
with sickle cell anemia (HbSS), HbSC disease, and HbS-β+-thalassemia. The packed cell …

Sickle cell disease (SCD) is a collection of inherited blood disorders that affect a substantial
number of people in the US, particularly African Americans. People with SCD have an …

Sickle cell trait continues to be the leading cause of sudden death for young African
Americans in military basic training and civilian organized sports. The syndrome may have …

The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary
selection at least five times in the world because of its overwhelming malarial protective …