Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage

Y Kamanaka, K Kondo, Y Ikeda, W Kamoshima… - Life sciences, 2004 - Elsevier
N-[3-(4-Oxo-3, 4-dihydro-phthalazin-1-yl) phenyl]-4-(morpholin-4-yl) butanamide
methanesulfonate monohydrate (ONO-1924H) is a novel inhibitor of poly ADP-ribose …
被引用次数：33 相关文章 所有 8 个版本

Neuroprotective effects of a novel poly (ADP‐ribose) polymerase‐1 inhibitor, JPI‐289, in hypoxic rat cortical neurons

Y Kim, YS Kim, MY Noh, H Lee, B Joe… - Clinical and …, 2017 - Wiley Online Library
Excessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop
neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore …
被引用次数：22 相关文章 所有 9 个版本

Neuroprotective effects of a novel water-soluble poly (ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia

Y Egi, S Matsuura, T Maruyama, M Fujio, S Yuki… - Brain research, 2011 - Elsevier
Cerebral ischemia induces excessive activation of poly (ADP-ribose) polymerase-1 (PARP-
1), leading to neuronal cell death and the development of post-ischemic dysfunction …
被引用次数：33 相关文章 所有 7 个版本
[PDF] researchgate.net

Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat

XCM Lu, E Massuda, Q Lin, W Li, JH Li, J Zhang - Brain research, 2003 - Elsevier
Poly (ADP-ribose) is synthesized from nicotinamide adenine dinucleotide (NAD+) by poly
(ADP-ribose) polymerase (PARP) and degraded by poly (ADP-ribose) glycohydrolase …
被引用次数：91 相关文章 所有 10 个版本

Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly (ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat

VC Besson, Z Zsengellér, M Plotkine, C Szabó… - Brain research, 2005 - Elsevier
Traumatic brain injury produces peroxynitrite, a powerful oxidant which triggers DNA strand
breaks, leading to the activation of poly (ADP-ribose) polymerase-1 (PARP-1). We …
被引用次数：65 相关文章 所有 7 个版本

Towards new neuroprotective agents: design and synthesis of 4H-thieno [2, 3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors

R Pellicciari, E Camaioni, G Costantino, M Marinozzi… - Il Farmaco, 2003 - Elsevier
An excessive activation of poly (ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme
able to catalyze the transfer of ADP-ribose from NAD to acceptor proteins, is involved in the …
被引用次数：39 相关文章 所有 9 个版本
[PDF] nature.com

Poly (ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

F Moroni, E Meli, F Peruginelli, A Chiarugi… - Cell Death & …, 2001 - nature.com
An excessive activation of poly (ADP-ribose) polymerase (PARP) has been proposed to play
a key role in post-ischemic neuronal death. We examined the neuroprotective effects of the …
被引用次数：190 相关文章 所有 9 个版本

Protective effects of PJ34, a novel, potent inhibitor of poly (ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke

GE Abdelkarim, K Gertz, C Harms… - International …, 2001 - spandidos-publications.com
Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …
被引用次数：313 相关文章 所有 9 个版本

[引用][C] A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3, 6-dihydro-1 (2H)-pyridinyl) propyl]-4 (3H)-quinazolinone) …

A Iwashita, N Tojo, S Matsuura, S Yamazaki… - … of Pharmacology and …, 2004 - ASPET
被引用次数：98 相关文章 所有 4 个版本

[引用][C] Neuroprotective effects of a novel poly (ADP-ribose) polymerase-1 inhibitor, 2-{3-[4-(4-chlorophenyl)-1-piperazinyl] propyl}-4 (3H)-quinazolinone (FR255595) …

A Iwashita, S Yamazaki, K Mihara, K Hattori… - … of Pharmacology and …, 2004 - ASPET
被引用次数：90 相关文章 所有 6 个版本