The approximability of shortest path-based graph orientations of protein–protein interaction networks
D Blokh, D Segev, R Sharan - Journal of Computational Biology, 2013 - liebertpub.com
The graph orientation problem calls for orienting the edges of an undirected graph so as to
maximize the number of prespecified source-target vertex pairs that admit a directed path …
maximize the number of prespecified source-target vertex pairs that admit a directed path …
Network orientation via shortest paths
D Silverbush, R Sharan - Bioinformatics, 2014 - academic.oup.com
The graph orientation problem calls for orienting the edges of a graph so as to maximize the
number of pre-specified source–target vertex pairs that admit a directed path from the source …
number of pre-specified source–target vertex pairs that admit a directed path from the source …
Approximation algorithms for orienting mixed graphs
M Elberfeld, D Segev, CR Davidson… - Theoretical Computer …, 2013 - Elsevier
Graph orientation is a fundamental problem in graph theory that has recently arisen in the
study of signaling-regulatory pathways in protein networks. Given a graph and a list of …
study of signaling-regulatory pathways in protein networks. Given a graph and a list of …
Approximation algorithms and hardness results for shortest path based graph orientations
D Blokh, D Segev, R Sharan - … , CPM 2012, Helsinki, Finland, July 3-5 …, 2012 - Springer
The graph orientation problem calls for orienting the edges of an undirected graph so as to
maximize the number of pre-specified source-target vertex pairs that admit a directed path …
maximize the number of pre-specified source-target vertex pairs that admit a directed path …
An algorithm for orienting graphs based on cause-effect pairs and its applications to orienting protein networks
We consider a graph orientation problem arising in the study of biological networks. Given
an undirected graph and a list of ordered source-target pairs, the goal is to orient the graph …
an undirected graph and a list of ordered source-target pairs, the goal is to orient the graph …
Improved orientations of physical networks
I Gamzu, D Segev, R Sharan - … , WABI 2010, Liverpool, UK, September 6-8 …, 2010 - Springer
The orientation of physical networks is a prime task in deciphering the signaling-regulatory
circuitry of the cell. One manifestation of this computational task is as a maximum graph …
circuitry of the cell. One manifestation of this computational task is as a maximum graph …
Exploiting bounded signal flow for graph orientation based on cause–effect pairs
Background We consider the following problem: Given an undirected network and a set of
sender–receiver pairs, direct all edges such that the maximum number of" signal flows" …
sender–receiver pairs, direct all edges such that the maximum number of" signal flows" …
On the approximability of reachability-preserving network orientations
M Elberfeld, V Bafna, I Gamzu, A Medvedovsky… - Internet …, 2011 - Taylor & Francis
We introduce a graph-orientation problem arising in the study of biological networks. Given
an undirected graph and a list of ordered source–target vertex pairs, the goal is to orient the …
an undirected graph and a list of ordered source–target vertex pairs, the goal is to orient the …
Optimally orienting physical networks
D Silverbush, M Elberfeld, R Sharan - Journal of Computational …, 2011 - liebertpub.com
In a network orientation problem, one is given a mixed graph, consisting of directed and
undirected edges, and a set of source-target vertex pairs. The goal is to orient the undirected …
undirected edges, and a set of source-target vertex pairs. The goal is to orient the undirected …
Connectivity problems on heterogeneous graphs
Background Network connectivity problems are abundant in computational biology
research, where graphs are used to represent a range of phenomena: from physical …
research, where graphs are used to represent a range of phenomena: from physical …
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