Medical lipid-regulating therapy: current evidence, ongoing trials and future developments

M Evans, A Roberts, S Davies, A Rees - Drugs, 2004 - Springer
Coronary heart disease (CHD) is a major cause of morbidity and mortality worldwide.
Elevated low density lipoprotein-cholesterol (LDL-C) and reduced high density lipoprotein …

The power of statins: aggressive lipid lowering

EA Stein - Clinical Cardiology: An International Indexed and …, 2003 - Wiley Online Library
A large body of evidence has demonstrated that reductions in low‐density lipoprotein
cholesterol (LDL‐C) decrease the risk of coronary heart disease (CHD) and related adverse …

Current and future aims of lipid-lowering therapy: changing paradigms and lessons from the heart protection study on standards of efficacyand safety

CM Ballantyne - The American journal of cardiology, 2003 - Elsevier
Lipid-lowering guidelines continue to evolve toward the use of (1) global risk assessment,(2)
lipid measures other than or in addition to low-density lipoprotein (LDL) cholesterol in …

Lowering LDL cholesterol: questions from recent meta-analyses and subset analyses of clinical trial data issues from the Interdisciplinary Council on Reducing the …

AM Gotto Jr, SM Grundy - Circulation, 1999 - Am Heart Assoc
The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease
(CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival …

Update on the efficacy and safety of combination ezetimibe plus statin therapy

PP Toth, A Catapano, JE Tomassini… - Clinical Lipidology …, 2010 - search.proquest.com
The primary aim of lipid-related cardiovascular disease (CVD) risk management is the
lowering of LDL-C levels. Numerous studies have shown that statins, which inhibit …

Aggressive lipid-lowering therapy: a clinical imperative.

TR Pedersen - European heart journal, 1998 - europepmc.org
Overwhelming evidence from epidemiological and clinical studies has demonstrated that
low density lipoprotein cholesterol (LDL-C) is a key element in the development of …

Ezetimibe: an update on its clinical usefulness in specific patient groups

D Hammersley, M Signy - Therapeutic advances in chronic …, 2017 - journals.sagepub.com
The aim of pharmacological lipid modification is to reduce low-density lipoprotein
cholesterol (LDL-C) as a means of either secondary or primary prevention of cardiovascular …

Optimising treatment of hyperlipidaemia: quantitative evaluation of UK, USA and European guidelines taking account of both LDL cholesterol levels and …

H Soran, S Adam, PN Durrington - Atherosclerosis, 2018 - Elsevier
Background and aims Guidelines for cholesterol-lowering medication either advocate fixed
dose statin treatment without low density lipoprotein (LDL) cholesterol targets or treatment …

[HTML][HTML] Evidence-based goals in LDL-C reduction

H Soran, R Dent, P Durrington - Clinical research in cardiology, 2017 - Springer
The evidence from trials of statin therapy suggests that benefits in cardiovascular disease
(CVD) event reduction are proportional to the magnitude of low-density lipoprotein …

[HTML][HTML] Management of hypercholesterolemia, appropriateness of therapeutic approaches and new drugs in patients with high cardiovascular risk

E Agabiti Rosei, M Salvetti - High Blood Pressure & Cardiovascular …, 2016 - Springer
Control of lipid levels is one of the most effective strategies for cardiovascular (CV) event
prevention. In fact, many clinical trials have clearly demonstrated that low-density lipoprotein …