Regulatory T (Treg) cells are found at elevated densities in many human cancers and are
thought to be a major barrier to the generation of robust antitumor T cell responses. In this …

The inflammatory response to transformed cells forms the cornerstone of natural or
therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

The immune system mediates powerful effector mechanisms to protect against a diversity of
pathogens and equally as important regulatory functions, to limit collateral damage of …

The immune system has evolved complex effector mechanisms to protect the host against a
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …

Importance of the field: The active suppression of immune responses against tumor is a
major barrier to the likely success of cancer immunotherapy. There is now compelling …

Regulatory T cells (Tregs) play pivotal roles in limiting the duration and magnitude of
immune response against infectious agents and self-antigens. This is accomplished through …

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …

Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the
development of autoimmune diseases. However, Treg cells are abundant in tumors and …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …