COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk
JE Goodman, JA Lavigne, K Wu, KJ Helzlsouer… - …, 2001 - academic.oup.com
Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens
(CEs), using S-adenosylmethionine (SAM) as a methyl donor. Several studies have …
(CEs), using S-adenosylmethionine (SAM) as a methyl donor. Several studies have …
Genetic Polymorphisms in Catechol-O-Methyltransferase, Menopausal Status, and Breast Cancer Risk
Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of estrogen
catechols. In a case-control study, we evaluated the association of the low-activity allele …
catechols. In a case-control study, we evaluated the association of the low-activity allele …
An Association between the Allele Coding for a Low Activity Variant of Catechol-O-methyltransferase and the Risk for Breast Cancer
JA Lavigne, KJ Helzlsouer, HY Huang, PT Strickland… - Cancer Research, 1997 - AACR
Mounting evidence suggests that catechol metabolites of estradiol may contribute to the
development of estrogen-induced cancers. O-Methylation, catalyzed by catechol-O …
development of estrogen-induced cancers. O-Methylation, catalyzed by catechol-O …
Breast Cancer Risk Reduction and Membrane-Bound Catechol O-Methyltransferase Genetic Polymorphisms
Y Ji, J Olson, J Zhang, M Hildebrandt, L Wang, J Ingle… - Cancer research, 2008 - AACR
Abstract Catechol O-methyltransferase (COMT)-catalyzed methylation of catecholestrogens
has been proposed to play a protective role in estrogen-induced genotoxic carcinogenesis …
has been proposed to play a protective role in estrogen-induced genotoxic carcinogenesis …
Catechol-O-Methyltransferase (COMT)-mediated Metabolism of Catechol Estrogens: Comparison of Wild-Type and Variant COMT Isoforms
S Dawling, N Roodi, RL Mernaugh, X Wang, FF Parl - Cancer research, 2001 - AACR
The oxidative metabolism of 17β-estradiol (E2) and estrone (E1) to catechol estrogens (2-
OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a …
OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a …
Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria
B Lajin, AR Hamzeh, L Ghabreau, A Mohamed… - Breast Cancer, 2013 - Springer
Abstract Background Catechol-O-methyltransferase (COMT) inactivates catechol estrogens
by methylation and thus may play a protective role against mutations induced by estrogen …
by methylation and thus may play a protective role against mutations induced by estrogen …
Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women
M Bergman-Jungeström, S Wingren - British journal of cancer, 2001 - nature.com
Oestrogen exposure has long been considered to be a main risk factor of breast cancer.
More recently, interest has also focused on the possible carcinogenic influence from …
More recently, interest has also focused on the possible carcinogenic influence from …
The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols
K Sak - Drug Metabolism Reviews, 2017 - Taylor & Francis
Abstract Catechol-O-methyltransferase, COMT, is an important phase II enzyme catalyzing
the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate …
the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate …
Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: A nested case–control study in Taiwan
Background: Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-
methylation of catechol estrogens, which are hypothesized to participate in estrogen …
methylation of catechol estrogens, which are hypothesized to participate in estrogen …
Catechol-O-methyltransferase: characteristics, polymorphisms and role in breast cancer
JD Yager - Drug Discovery Today: Disease Mechanisms, 2012 - Elsevier
Catechol estrogens are carcinogenic, probably because of their estrogenicity and potential
for further oxidative metabolism to reactive quinones. Estrogenic quinones cause oxidative …
for further oxidative metabolism to reactive quinones. Estrogenic quinones cause oxidative …