Targeted modulation of immune cells and tissues using engineered biomaterials

P Yousefpour, K Ni, DJ Irvine - Nature reviews bioengineering, 2023 - nature.com
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Biomaterial strategies for immunomodulation

NA Hotaling, L Tang, DJ Irvine… - Annual review of …, 2015 - annualreviews.org
Strategies to enhance, suppress, or qualitatively shape the immune response are of
importance for diverse biomedical applications, such as the development of new vaccines …

Biomaterials-mediated engineering of the immune system

C Backlund, S Jalili-Firoozinezhad… - Annual review of …, 2023 - annualreviews.org
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Biomaterials for enhancing anti-cancer immunity

ST Koshy, DJ Mooney - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Biomaterials can potentially improve the safety and efficacy of cancer
immunotherapy.•Biomaterials scaffolds can program immune cell function in peripheral …

Harnessing biomaterials to engineer the lymph node microenvironment for immunity or tolerance

JI Andorko, KL Hess, CM Jewell - The AAPS journal, 2015 - Springer
Nanoparticles, microparticles, and other biomaterials are advantageous in vaccination
because these materials provide opportunities to modulate specific characteristics of …

Designing natural and synthetic immune tissues

EA Gosselin, HB Eppler, JS Bromberg, CM Jewell - Nature materials, 2018 - nature.com
Vaccines and immunotherapies have provided enormous improvements for public health,
but there are fundamental disconnects between where most studies are performed—in cell …

Harnessing innate immunity using biomaterials for cancer immunotherapy

DY Lee, K Huntoon, Y Wang, W Jiang… - Advanced …, 2021 - Wiley Online Library
The discovery of immune checkpoint blockade has revolutionized the field of immuno‐
oncology and established the foundation for developing various new therapies that can …

[HTML][HTML] Bioengineering of artificial antigen presenting cells and lymphoid organs

C Wang, W Sun, Y Ye, HN Bomba, Z Gu - Theranostics, 2017 - ncbi.nlm.nih.gov
The immune system protects the body against a wide range of infectious diseases and
cancer by leveraging the efficiency of immune cells and lymphoid organs. Over the past …

Macroscale biomaterials strategies for local immunomodulation

MO Dellacherie, BR Seo, DJ Mooney - Nature Reviews Materials, 2019 - nature.com
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …

Immunologically effective biomaterials

Q Wei, Y Su, H Xin, L Zhang, J Ding… - ACS Applied Materials & …, 2021 - ACS Publications
Immunoregulation represents a booming field of biomaterial design. The unique physical
and chemical properties of biomaterials offer tremendous opportunities for development …