The present study was undertaken to examine the effects of the ACE (angiotensin converting
enzyme) inhibitor imidapril, on the brain, when administered after the onset of stroke in a …

Intracerebral hemorrhage (ICH) was widely believed to be a monophasic event whereby cell
death occurs from the initial space-occupying effects of the hematoma. However, we now …

Background The insulin-like growth factor 2 (IGF-2) is a growth factor and anti-inflammatory
cytokine that plays a crucial role in memory consolidation. However, the precise role of this …

Knowing that progesterone up-regulates PDGF-A, which plays a relevant role in
angiogenesis, and that imatinib mesylate targets PDGF receptor tyrosine kinase activity, the …

Thrombin is thought to play an important role in brain damage associated with intracerebral
hemorrhage (ICH). We previously showed that activation of mitogen-activated protein (MAP) …

Intracerebral hemorrhage (ICH) is a devastating neurological disorder with high mortality
and poor prognosis, for which virtually no effective drug therapies are available at present …

Lactate accumulation has been observed in the brain with intracerebral hemorrhage (ICH).
However, the outcome of lactate accumulation has not been well characterized. Here, we …

Stroke is the major cause of death and decrease in the activities of daily living. This study
sought to evaluate the effects of commonly used antiplatelet drugs on spontaneous cerebral …

Aim Insulin‐like growth factor I (IGF‐I) is a neuroprotective agent in animal models of
ischemic stroke. The purpose of this study was to determine whether systemically injected …

The binding of platelet glycoprotein (GP) IIb/IIIa to fibrinogen is the final common pathway in
platelet aggregation, a process known to play a key role in the pathogenesis of ischemic …