Human gut-associated natural killer cells in health and disease

A Poggi, R Benelli, R Venè, D Costa, N Ferrari… - Frontiers in …, 2019 - frontiersin.org
It is well established that natural killer (NK) cells are involved in both innate and adaptive
immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals …

Potential role of NK cells in the pathogenesis of inflammatory bowel disease

PK Yadav, C Chen, Z Liu - BioMed Research International, 2011 - Wiley Online Library
NK cells are a major component of the innate immune system and play an important role in
the tissue inflammation associated with autoimmune diseases such as inflammatory bowel …

[HTML][HTML] NKT cells in mucosal immunity

S Middendorp, EES Nieuwenhuis - Mucosal immunology, 2009 - Elsevier
The gastrointestinal tract allows the residence of an almost enumerable number of bacteria.
To maintain homeostasis, the mucosal immune system must remain tolerant to the …

The functions of type I and type II natural killer T cells in inflammatory bowel diseases

CM Liao, MI Zimmer, CR Wang - Inflammatory bowel diseases, 2013 - academic.oup.com
CD1d-restricted natural killer T (NKT) cells are a distinct subset of T cells that rapidly
produce an array of cytokines on activation and play a critical role in regulating various …

[HTML][HTML] Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor

LJ Hall, CT Murphy, A Quinlan, G Hurley… - Mucosal …, 2013 - Elsevier
Natural killer (NK) cells are traditionally considered in the context of tumor surveillance and
infection defense but their role in chronic inflammatory disorders such as inflammatory …

The role of natural killer cells in autoimmune liver disease: a comprehensive review

K Hudspeth, E Pontarini, P Tentorio, M Cimino… - Journal of …, 2013 - Elsevier
Natural Killer (NK) cells are important players of the innate arm of the immune system and
provide an early defense against pathogens and tumor-transformed cells. Peripheral blood …

Human small-intestinal epithelium contains functional natural killer lymphocytes

F León, E Roldán, L Sanchez, C Camarero, A Bootello… - Gastroenterology, 2003 - Elsevier
BACKGROUND & AIMS:: CD3− non-T lymphocytes constitute the second most abundant
lymphoid subset in the human small-bowel epithelium, and these CD3− intraepithelial …

Organ-specific features of natural killer cells

FD Shi, HG Ljunggren, A La Cava… - Nature Reviews …, 2011 - nature.com
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

NK cells in immunotolerant organs

H Sun, C Sun, Z Tian, W Xiao - Cellular & molecular immunology, 2013 - nature.com
Organs such as the liver, uterus and lung possess hallmark immunotolerant features,
making these organs important for sustaining self-homeostasis. These organs contain a …

Increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment

AW Steel, CM Mela, JO Lindsay… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 33: 115–126 Summary Background Distinct functional
subsets of natural killer cells potentially contribute to the pathology of inflammatory bowel …