Cellular reprogramming of somatic cells to human pluripotent stem cells (iPSC) represents
an efficient tool for in vitro modeling of human brain diseases and provides an innovative …

Parkinson's disease (PD) is an age-related neurodegenerative disorder with no known cure.
In order to better understand the pathological mechanisms which lead to neuronal cell death …

Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with
characteristic movement impairments that are caused by the progressive loss of dopamine …

Progress in understanding neurodegenerative cell biology in Parkinson′ s disease (PD)
has been hampered by a lack of predictive and relevant cellular models. In addition, the lack …

Induced pluripotent stem cells (iPSCs) are becoming an important source of pre-clinical
models for research focusing on neurodegeneration. They offer the possibility for better …

Parkinson's disease (PD), a common degenerative disease in humans, is known to result
from loss of dopamine neurons in the substantia nigra and is characterized by severe motor …

Parkinson's disease (PD) is an age-related neurodegenerative disease caused by the
progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons …

Studying Parkinson's disease (PD) in the laboratory presents many challenges, the main
one being the limited availability of human cells and tissue from affected individuals. As PD …

The prevalence and incidence of Parkinson's disease (PD) is increasing due to a prolonged
life expectancy. This highlights the need for a better mechanistic understanding and new …

Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human
disease in relevant cell types, but it is unclear whether they could successfully model age …