Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …

The INK4a/ARF locus on human chromosome 9p21 encodes two tumor suppressors,
p16INK4a and p14ARF, that restrain cell growth by affecting the functions of the …

The cyclin-dependent kinase inhibitor p16INK4a encoded by the INK4A/CDKN2A/MTS1
gene is a frequent target of 9p21 inactivation in human lung cancers. The p14ARF transcript …

Background: The p14ARF protein encoded by the INK4a/ARF locus promotes degradation
of the MDM2 protein and thus prevents the MDM2-mediated inhibition of p53. Homozygous …

p14ARF tumor suppressor protein regulates p53 by interfering with mdm2–p53 interaction.
p14ARF is activated in response to oncogenic stimuli but little is known of the responses of …

p14ARF, the alternative product from the human INK4a/ARF locus, antagonizes Hdm2 and
mediates p53 activation in response to oncogenic stimuli. An immunohistochemical study of …

Abstract p19ARF is a tumor suppressor that is frequently deleted in human cancer. It lies at
chromosome 9p21 and shares exons 2 and 3 with p16ink4a, which is also inactivated by …

The p53-mediated pathway cell cycle arrest and apoptosis is central to cancer and an
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …

Weakening the Spindle Assembly Checkpoint by reduced expression of its components
induces chromosome instability and aneuploidy that are hallmarks of cancer cells. The …

The INK4a/ARF locus on the short arm of chromosome 9 is one of the most frequently
altered loci in human cancer. It is generally accepted that ARF is involved in oncogenic …