p14ARF is a tumor suppressor that controls a well-described p53/Mdm2-dependent
checkpoint in response to oncogenic signals. Here, new insights into the tumor-suppressive …

p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …

Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …

The INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16 INK4a
and p14 ARF. Although the former is one of the most common targets for inactivation in …

Abstract P14 ARF (p19 ARF in the mouse) plays a central role in the regulation of cellular
proliferation. Although the capacity of p14 ARF to induce a cell cycle arrest in G1 phase …

While p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the
mechanism by which p14ARF inhibits tumorigenesis independently of p53 remains elusive …

Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …

The p53 tumor suppressor is a stress sensor, driving cell cycle arrest or apoptosis in
response to DNA damage or oncogenic signals. p53 activation by oncogenic signals relies …

The p14ARF tumor suppressor triggers cell death or cell cycle arrest upon oncogenic stress.
In MCF‐7 breast carcinoma cells, expression of the tumor suppressor gene p14ARF fails to …

The ARF (p19ARF for the mouse ARF consisting of 169 amino acids and p14ARF for the
human ARF consisting of 132 amino acids) genes upregulate p53 activities to induce cell …