p14ARF induces G2 cell cycle arrest in p53-and p21-deficient cells by down-regulating p34cdc2 kinase activity
G Normand, PG Hemmati, B Verdoodt… - Journal of Biological …, 2005 - ASBMB
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
Aberrant expression of p14ARF in human cancers: A new biomarker?
K Inoue, EA Fry - Tumor and Microenvironment, 2018 - journals.lww.com
The ARF and INK4a genes are located on the same CDKN2a locus, both showing its tumor-
suppressive activity. ARF has been shown to monitor potentially harmful oncogenic …
suppressive activity. ARF has been shown to monitor potentially harmful oncogenic …
Association of p14ARF with the p120E4FTranscriptional Repressor Enhances Cell Cycle Inhibition
H Rizos, E Diefenbach, P Badhwar, S Woodruff… - Journal of Biological …, 2003 - ASBMB
The p14 ARF tumor suppressor is a key regulator of cellular proliferation and is frequently
inactivated in human cancer. This tumor suppressor functions in the p53 and pRb cell cycle …
inactivated in human cancer. This tumor suppressor functions in the p53 and pRb cell cycle …
p19 Arf Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways
KS Kelly-Spratt, KE Gurley, Y Yasui, CJ Kemp - PLoS biology, 2004 - journals.plos.org
Ectopic expression of oncogenes such as Ras induces expression of p19Arf, which, in turn,
activates p53 and growth arrest. Here, we used a multistage model of squamous cell …
activates p53 and growth arrest. Here, we used a multistage model of squamous cell …
ARF regulates the stability of p16 protein via REGγ-dependent proteasome degradation
T Kobayashi, J Wang, H Al-Ahmadie… - Molecular Cancer …, 2013 - AACR
The cell-cycle regulatory gene INK4A-ARF (CDKN2A) has two alternative transcripts that
produce entirely different proteins, namely p14ARF and p16, which have complementary …
produce entirely different proteins, namely p14ARF and p16, which have complementary …
Non-canonical functions of the ARF tumor suppressor in development and tumorigenesis
N Lagopati, K Belogiannis, A Angelopoulou… - Biomolecules, 2021 - mdpi.com
P14ARF (ARF; Alternative Reading Frame) is an extensively characterized tumor
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …
Dual role of the alternative reading frame ARF protein in cancer
The CDKN2a/ARF locus expresses two partially overlapping transcripts that encode two
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
p14ARF Expression Increases Dihydrofolate Reductase Degradation and Paradoxically Results in Resistance to Folate Antagonists in Cells with Nonfunctional p53
PG Magro, AJ Russo, WW Li, D Banerjee, JR Bertino - Cancer research, 2004 - AACR
The p14ARF protein, the product of an alternate reading frame of the INK4A/ARF locus on
human chromosome 9p21, disrupts the ability of MDM2 to target p53 for proteosomal …
human chromosome 9p21, disrupts the ability of MDM2 to target p53 for proteosomal …
p19ARF is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
D Tolbert, X Lu, C Yin, M Tantama… - Molecular and cellular …, 2002 - Am Soc Microbiol
Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …
oncogenic stress by regulating the activity of p53. This response is mediated by …
Tumor suppression by Ink4a–Arf: progress and puzzles
SW Lowe, CJ Sherr - Current opinion in genetics & development, 2003 - Elsevier
The two products of the Ink4a–Arf locus, p16Ink4a and p19Arf (p14ARF in humans), are
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …